Dichloromethane → HCID 20076964, 화합물

HRID 1654916노트

반응식

HRID 1654916 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.ClCCl.[OH-].[Na+].[F:14][C:15]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:16]=1[CH2:17]Br>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].O>[NH2:1][C:2]1[C:7]([O:8][CH2:17][C:16]2[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:15]=2[F:14])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 281142-Amino-3-HydroxypyridineHCID 109550331-(Bromomethyl)-2-fluoro-4-methoxybenzene

생성물 1

HCID 20076964HCID 20076964, 화합물

시약·촉매·용매 2

HCID 21218Trioctylmethylammonium chloride촉매HCID 962Water용매

실험 절차

A mixture of 2-amino-3-hydroxy pyridine (1.45g, 0.013 mol), dichloromethane (10 ml) and 40% aqueous sodium hydroxide solution (10 ml) was stirred for five minutes, then 2-fluoro-4-methoxybenzyl bromide (2.9 g, 0.013 mol) and Adogen 464 (1.5 ml) were added and stirring continued for 16 hours. The mixture was diluted with water and extracted with dichloromethane. Drying and evaporation of the organic extracts, and trituration with ether gave the desired product. Yield 1.11 g (34%), m.p. 135°-138 ° C.

후처리

  1. stirringstirring
  2. waitcontinued for 16 hours
  3. extractionextracted with dichloromethane
  4. customDrying
  5. customevaporation of the organic extracts, and trituration with ether

출처 및 근거

ORD 기록
ord-b05def9f119c48999a142c4a4225eb8e
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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