Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol

HRID 1654941노트

반응식

HRID 1654941 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C[O:8][C:9](=O)[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1.O.[OH-].[Na+]>O1CCCC1>[CH2:19]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH:11]1[CH2:10][CH2:9][OH:8]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 103520002-(2,3-dihydro-1H-inden-2-yl)ethanol수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.02 g (26.8 mmol) of lithium aluminum hydride was suspended in 100 ml of tetrahydrofuran, to which was added dropwise a solution of 10 ml tetrafuran containing 5.06 g (26.6 mmol) of methyl(indan-2-yl)acetate under ice-cooling. After completion of the addition, stirring was continued for 1 hour, during which 1 ml water, 1 ml of 15% sodium hydroxide and 3 ml water were added dropwise in this order for decomposing the excessive reducing agent. The solid matter was removed by filtration, the filtrate was condensed and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4) to obtain 4.30 g of a colorless oil. Yield: 100%

후처리

  1. temperaturecooling
  2. additionAfter completion of the addition
  3. additionwere added dropwise in this order
  4. customThe solid matter was removed by filtration
  5. customcondensed
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4)

출처 및 근거

ORD 기록
ord-f03b3b53196c4a62a31e3c2dc29dff39
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409956

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