Acetyl chloride → HCID 20077196, 화합물

HRID 1654951노트

반응식

HRID 1654951 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19](=[O:21])[CH3:20])[CH:15]=2)[CH2:10]1

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetate

생성물 1

HCID 20077196HCID 20077196, 화합물수율 91%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

160 ml of methylene chloride was added with 52.9 g (0.388 mol) of anhydrous aluminum chloride, and further added with 40 ml of methylene chloride containing 25.03 g (0.132 mol) of methyl(indan-2-yl)acetate under ice-cooling. Subsequently, 13.1 ml (0.185 mol) of acetyl chloride was added thereto dropwise. Stirring was conducted for 40 minutes at the same temperature. The reaction mixture was poured into ice-water and the organic phase was collected. After washing and drying, the solvent was condensed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2) to obtain 27.8 g of an oily product. Yield: 91%

후처리

  1. temperaturecooling
  2. customthe organic phase was collected
  3. washAfter washing
  4. customdrying
  5. customcondensed under reduced pressure
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2)

출처 및 근거

ORD 기록
ord-11aa938d732b4e16bbe408595e14c20b
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409956

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