Ethanol → HCID 178441542, 화합물

HRID 1655116

반응식

HRID 1655116 반응식
Cl.[CH2:2]([C:6]1[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[CH:8]=[C:9]([CH2:11][CH2:12][NH2:13])[N:10]=1)[CH2:3][CH2:4][CH3:5].[C:32]([O:36][CH2:37][CH3:38])(=[O:35])[CH:33]=O.C(O)C>C(Cl)(Cl)Cl>[CH2:2]([C:6]1[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:8]2[CH:33]([C:32]([O:36][CH2:37][CH3:38])=[O:35])[NH:13][CH2:12][CH2:11][C:9]=2[N:10]=1)[CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 3

HCID 702EthanolHCID 70211Ethyl oxoacetateHCID 1784416472-n-butyl-4-(2-aminoethyl)-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole hydrochloride

생성물 1

HCID 178441542HCID 178441542, 화합물수율 44.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 2-n-butyl-4-(2-aminoethyl)-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole hydrochloride (0.278 g), ethyl glyoxylate (0.179 g) and ethanol (5 ml) is refluxed for three days. To the mixture is added chloroform, and the mixture is washed, dried and evaporated to remove the solvent. The solvent is purified by silica gel column chromatography (solvent; chloroform/methanol=10.1) to give ethyl 2-n-butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (0.136 g) as a foam.

후처리

  1. temperatureis refluxed for three days
  2. washthe mixture is washed
  3. customdried
  4. customevaporated
  5. customto remove the solvent
  6. customThe solvent is purified by silica gel column chromatography (solvent; chloroform/methanol=10.1)

출처 및 근거

ORD 기록
ord-d51c637b15c3425cb38816d26022f7cb
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409936

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