Thionyl Chloride → 5-Bromo-4-amino-2-chloromethylpyridine hydrochloride

HRID 1655204노트

반응식

HRID 1655204 반응식
[Br:1][C:2]1[C:3]([NH2:10])=[CH:4][C:5]([CH2:8]O)=[N:6][CH:7]=1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[ClH:13].[Br:1][C:2]1[C:3]([NH2:10])=[CH:4][C:5]([CH2:8][Cl:13])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl Chloride2회HCID 17992217HCID 17992217, 화합물

생성물 1

HCID 179922125-Bromo-4-amino-2-chloromethylpyridine hydrochloride

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

5 -Bromo-4 -amino-2 -hydroxymethylpyridine (0.60 g, 0.003 M) in chloroform (15 ml) was cooled to -10 ° and thionyl chloride (0.64 ml, 1.05 g, 0.0089 M) in chloroform (5 ml) added dropwise over 20 minutes so that the temperature of the reaction mixture did not rise above -10°. The reaction mixture was stirred for 1 hour at -10 ° and then allowed to warm to room temperature and stirred for 21 hours (if the reaction is not complete at this stage, further portions of thionyl chloride can be added (at -10 °), followed by reflux if necessary).

후처리

  1. customdid not rise above -10°
  2. stirringstirred for 21 hours (if the reaction
  3. additioncan be added (at -10 °)
  4. temperatureby reflux if necessary)

출처 및 근거

ORD 기록
ord-1470f9b593de4137ba67645b6e7f5b0c
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250527

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