Ammonia → m-Nifedipine

HRID 1655306

반응식

HRID 1655306 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[C:12]([O:18][CH3:19])(=[O:17])[CH2:13][C:14]([CH3:16])=O.[NH3:20]>CO>[CH3:16][C:14]1[NH:20][C:14]([CH3:16])=[C:13]([C:12]([O:18][CH3:19])=[O:17])[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:13]=1[C:12]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 74493-NitrobenzaldehydeHCID 7757Methyl acetoacetate

생성물 1

HCID 89082m-Nifedipine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 75.5 g (0.50 mole) of 3-nitrobenzaldehyde, 116 g (1.00 mole) of methyl acetoacetate and 55 ml (1.50 mole) of 28% ammonia in 150 ml of methanol is heated under reflux for 5 hr.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 5 hr

출처 및 근거

ORD 기록
ord-f3feaca82fb24df7b0df36f342933841
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250543

연결된 노트

불러오는 중…