Hydrochloric Acid → HCID 13671877, 화합물

HRID 1655322노트

반응식

HRID 1655322 반응식
[NH2:1][CH:2]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4].[Cl:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.[ClH:27].C(OCC)(=O)C>C(O)C.CCCCCC>[ClH:17].[ClH:27].[C:5]1([CH:3]([OH:4])[CH:2]([NH:1][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 462682-Amino-1-phenyloctan-1-olHCID 79625Piperidine, 1-(3-chloropropyl)-

생성물 1

HCID 13671877HCID 13671877, 화합물수율 59%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8058Hexane용매

실험 절차

A mixture of (1RS,2RS)-2-amino-1-phenyloctan-1-ol (1.77 g, 8 mmol) and 1-(3-chloropropyl)piperidine (1.29 g, 8 mmol) was melted at 70° C. in a nitrogen atmosphere. The mixture was then heated at 110° to 120° C. for 3 hours. The reaction mixture was dissolved with heating in ethanol, followed by addition of concentrated hydrochloric acid (0.67 ml). Ethyl acetate was added and the resulting mixture was allowed to stand. Precipitated crystals were collected by filtration and washed with ethyl acetate and then with hexane to obtain 1.96 g of the title compound as white crystals (yield: 59%).

후처리

  1. temperatureThe mixture was then heated at 110° to 120° C. for 3 hours
  2. dissolutionThe reaction mixture was dissolved
  3. customPrecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-33defaaa5d474bbdae105d28b5990846
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250546

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