Methane → 4-(4-Aminophenoxy)phenol

HRID 1655444노트

반응식

HRID 1655444 반응식
[OH:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.C.C1COCC1.[H][H]>[Pt].C(OCC)(=O)C>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:16]=[CH:17][C:2]([OH:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1

참가 물질

7

반응물 4

HCID 297MethaneHCID 8028TetrahydrofuranHCID 1524504-(4-Nitrophenoxy)phenolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 152173634-(4-Aminophenoxy)phenol수율 96.2%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8857Ethyl Acetate용매

실험 절차

1-(4-Hydroxyphenoxy)-4-nitrobenzene X (8.93 g, 38.62 mmol), 0.5% platinum catalyst on activated charcoal (1.5 g), THF (100 mL), and ethyl acetate (20 mL) were charged into a 250 mL hydrogenation vessel. Hydrogenation was carried out under 60 psi of hydrogen at room temperature for 16 hr. The reaction mixture was filtered and the organic solvents were removed under reduced pressure at 40° C. to give 4-(4-aminophenoxy)phenol XI (8.10 g, 96.2% yield), mp 130°-4° C. The IR and 1H-NMR spectra agreed with the assigned structure.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe organic solvents were removed under reduced pressure at 40° C.

출처 및 근거

ORD 기록
ord-79fa8365654d416986b231c4af5c4489
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250667

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