Nitric Acid → HCID 19792129, 화합물

HRID 1655465노트

반응식

HRID 1655465 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N+:19]([O-])([OH:21])=[O:20]>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:19]([O-:21])=[O:20])[C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 19792116HCID 19792116, 화합물

생성물 1

HCID 19792129HCID 19792129, 화합물

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

To a solution of methyl 5-chloro-2-valerylaminobenzoate (13.4 g) in acetic anhydride (10 ml) was added dropwise, while stirring under ice-cooling, fuming nitric acid. The mixture was stirred for one hour at room temperature, then there was added ice water. The mixture was allowed to stand to give crystals. Recrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

후처리

  1. temperaturecooling
  2. stirringThe mixture was stirred for one hour at room temperature
  3. customto give crystals
  4. customRecrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

출처 및 근거

ORD 기록
ord-d6ae6d71e9d241edbda47ca09678da74
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250554

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