Hydrochloric Acid → (R)-(+)-2-(2-furyl)-3-methyl-1-butanol

HRID 1655761노트

반응식

HRID 1655761 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]([CH:16]([CH3:18])[CH3:17])[C:13](O)=[O:14].Cl>CCOCC.O1CCCC1>[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C@H:12]([CH:16]([CH3:18])[CH3:17])[CH2:13][OH:14]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 197908462-(Furan-2-yl)-3-methylbutanoic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 22847751(R)-(+)-2-(2-furyl)-3-methyl-1-butanol수율 75%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매2회

실험 절차

10.5 g (0.277 mol) of lithium aluminium hydride were suspended in 100 ml of absolute ether and treated while stirring within 10 minutes with 100 ml of absolute tetrahydrofuran. To this stirred suspension was added dropwise within 6-8 hours, while heating to reflux, 46.7 g (0.277 mol) of (+) 2-(2-furyl)-3-methylbutyric acid in 100 ml of absolute tetrahydrofuran. The reaction mixture was cooled and treated slowly with a 3N hydrochloric acid solution. The organic phase was separated, washed with water, dried and evaporated under reduced pressure. The remaining oil was distilled in a high vacuum, to obtain 32 g (75%) of (R)-(+)-2-(2-furyl)-3-methyl-1-butanol as a colorless liquid of 96% purity, boiling point 58°/39 Pa, [α]D20 =+2.5° (c=1%, ethanol).

후처리

  1. additiontreated
  2. additionTo this stirred suspension was added dropwise within 6-8 hours
  3. temperaturewhile heating
  4. temperatureto reflux
  5. temperatureThe reaction mixture was cooled
  6. customThe organic phase was separated
  7. washwashed with water
  8. customdried
  9. customevaporated under reduced pressure
  10. distillationThe remaining oil was distilled in a high vacuum

출처 및 근거

ORD 기록
ord-abea6673995d4b5aad664fae5fb317e1
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250517

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