(3-Aminopyrazin-2-yl)methanol → 3-Aminopyrazine-2-carbaldehyde
반응식
[NH2:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][N:7]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[C:3]([CH:8]=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1참가 물질
4
실험 절차
A suspension of 3-aminopyrazine methanol, 6.3 g (0.05 mol) and manganese dioxide (38.0 g) in 400 mL of chloroform is stirred at room temperature for two hours and the resulting solid is filtered off. The filtrate is evaporated to dryness which gives the desired product as a yellow crystalline solid, (5.00 g, 82% yield) having a melting point 110°-114° C.
후처리
- filtrationthe resulting solid is filtered off
- customThe filtrate is evaporated to dryness which
출처 및 근거
- ORD 기록
- ord-8911c2373d1a45c08ba16fc69c399d27
- 출처 데이터셋
- uspto-grants-1993_10
- 특허 번호
- US05252538
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