Acetic Acid → HCID 19789780, 화합물

HRID 1656107노트

반응식

HRID 1656107 반응식
[BH4-].[Na+].[CH2:3]([N:5]1[CH2:17][CH2:16][CH:15]2[CH:7]([NH:8][C:9]3[C:14]2=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:6]1)[CH3:4].[C:18](O)(=O)[CH3:19]>>[CH2:3]([N:5]1[CH2:17][CH2:16][CH:15]2[CH:7]([N:8]([CH2:18][CH3:19])[C:9]3[C:14]2=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:6]1)[CH3:4]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 4311764Sodium borohydride2회HCID 19789750HCID 19789750, 화합물

생성물 1

HCID 19789780HCID 19789780, 화합물

실험 절차

NaBH4 (1.08 g) was added under ice-cooling to a solution of 2-ethyl-1,2,3,4,4a,9a-hexahydro-pyrido[3,4-b]indole (1.16 g) in 40 ml of acetic acid. After stirring the solution at room temperature for 4 hrs, additional NaBH4 (0.54 g) was added and the mixture was stirred for 3 hrs. After removal of acetic acid by evaporation, the residue was neutralized with ammonia, extracted with ethyl acetate, washed with brine and dried over magnesium sulfate. The solvent was evaporated off, thereby affording 1.26 g of the title compound as a pale yellow oil.

후처리

  1. stirringthe mixture was stirred for 3 hrs
  2. customAfter removal of acetic acid
  3. customby evaporation
  4. extractionextracted with ethyl acetate
  5. washwashed with brine
  6. dry with materialdried over magnesium sulfate
  7. customThe solvent was evaporated off

출처 및 근거

ORD 기록
ord-c47fafc96c4e40bca01b51820d8e3c6e
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05252580

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