Hydrochloric Acid → 3-Pyridinebutanol

HRID 1656311노트

반응식

HRID 1656311 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][CH2:9][CH2:10][O:11]C2CCCCO2)[CH:2]=1.Cl>CO.O.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[CH:2]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 539444502-[4-(3-Pyridyl)but-3-enoxy]tetrahydropyran

생성물 1

HCID 134191363-Pyridinebutanol수율 241.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 22242641Methanol--water (1/1)용매

실험 절차

10 g (43 mmol) of 2-[4-(3-pyridyl)but-3-enoxy]tetrahydropyran in 200 ml of methanol/water 1:1 (v/v) is acidified by 2N hydrochloric acid and hydrogenated for 16 hours over 2 g 10% palladium on carbon. After filtration, the solvent is removed, the remaining residue is neutralized by saturated aqueous bicarbonate, and the product is extraced with several portions of ether. Purification of the crude product by column chromatography on silica gel yields 15.7 g (87%) of 4-(3-pyridyl)but-Anol as colourless viscous oil. (C9H13NO; F.W. 151.2).

후처리

  1. filtrationAfter filtration
  2. customthe solvent is removed
  3. customPurification of the crude product by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-f25440d9186642c1840fccd1a2b923db
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254549

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