Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1656517노트

반응식

HRID 1656517 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[O:11]1CC[CH2:13][CH2:12]1>C(O)C>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 145174-Fluorobenzonitrile

생성물 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 4-fluorobenzonitrile (50 g) in tetrahydrofuran (300 mL) and ethanol (60.5 mL) at 0° C. was saturated with anhydrous hydrogen chloride gas and the resulting solution was allowed to stand overnight. The solvent was evaporated and the resulting solid was collected and washed with ether to provide ethyl 4-fluorobenzimidate hydrochloride as a white solid (20 g); NMR: 8.27 (m,2), 7.51 (m,2), 4.63 (q,2), 1.47 (t,3).

후처리

  1. customat 0° C.
  2. customThe solvent was evaporated
  3. customthe resulting solid was collected
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-c1a6320558b6436bb8ca96d5073c58a1
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254558

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