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Water → N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(4-acetamidophenoxy)-propanamine

HRID 1656647
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HRID 1656647 반응식
[NH2:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:12]([NH:15][C:16]1[CH:26]=[CH:25][C:19]([O:20][CH2:21][CH:22]2[O:24][CH2:23]2)=[CH:18][CH:17]=1)(=[O:14])[CH3:13].O>CS(C)=O>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11][CH:2]1[NH:1][CH2:23][CH:22]([OH:24])[CH2:21][O:20][C:19]1[CH:25]=[CH:26][C:16]([NH:15][C:12](=[O:14])[CH3:13])=[CH:17][CH:18]=1
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참가 물질

5

반응물 3

HCID 962WaterHCID 346772-AminotetralinHCID 2798712N-(4-((oxiran-2-yl)methoxy)phenyl)acetamide

생성물 1

HCID 19788327N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(4-acetamidophenoxy)-propanamine수율 35.7%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2-aminotetralin (2.5 g) and 1-(4-acetamidophenoxy)-2,3-epoxypropane (3.52 g) in dimethylsulfoxide (40 ml) is heated at 80° C. for 5 hours. The reaction mixture is allowed to cool toat room temperature and water (180 ml) is then added thereto. The precipitate which forms is recovered by filtration and crystallized from absolute ethanol (120 ml) yielding 2.15 g of N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(4-acetamidophenoxy)-propanamine; m.p. 133°-136° C.

후처리

  1. temperatureto cool toat room temperature
  2. filtrationThe precipitate which forms is recovered by filtration
  3. customcrystallized from absolute ethanol (120 ml)

출처 및 근거

ORD 기록
ord-3f73e23a7264437daa68db8f0162658b
출처 데이터셋
uspto-grants-1993_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05254595

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