2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 1656704

반응식

HRID 1656704 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

참가 물질

4

반응물 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

생성물 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

685 g (2.74 mol) of o-bromobenzyl bromide are refluxed together with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. The mixture is cooled and then concentrated, the residue is taken up in ethyl acetate, and the solution is washed with water. The organic phase is dried over sodium sulfate and then concentrated. 478.2 g (87%) of product are obtained as a colorless liquid.

후처리

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated
  3. washthe solution is washed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ac990156198e4b42a08f29931fbd0efa
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254717

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