Diisopropyl Ether → 2-Amino-5-bromo-4-methyl-1,3-thiazole hydrochloride

HRID 1656934노트

반응식

HRID 1656934 반응식
[ClH:1].[NH2:2][C:3]1[S:4][CH:5]=[C:6]([CH3:8])[N:7]=1.[Br:9]N1C(=O)CCC1=O.C(OC(C)C)(C)C>C(O)(=O)C>[ClH:1].[NH2:2][C:3]1[S:4][C:5]([Br:9])=[C:6]([CH3:8])[N:7]=1

참가 물질

5

반응물 3

HCID 7914Diisopropyl EtherHCID 67184N-bromobutanimideHCID 802402-Thiazolamine, 4-methyl-, hydrochloride (1:1)

생성물 1

HCID 189547282-Amino-5-bromo-4-methyl-1,3-thiazole hydrochloride수율 89.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-amino-4-methylthiazole hydrochloride (3.0 g) in acetic acid (20 ml) was added once N-bromosuccinimide (4.0 g) at room temperature with stirring. The mixture was stirred at room temperature for 1.5 hours and the reaction mixture was poured into isopropyl ether under ice cooling. The precipitates were collected by filtration, washed with ethyl ether and dried in vacuo to give 2-amino-5-bromo-4-methylthiazole hydrochloride (4.1 g, yield: 89.1%).

후처리

  1. stirringThe mixture was stirred at room temperature for 1.5 hours
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with ethyl ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-5e4a4947972144dcb8057233d69acbbd
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256675

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