Acetic Anhydride → 2-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole

HRID 1656972노트

반응식

HRID 1656972 반응식
C(O[C:5](=[O:7])C)(=O)C.[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]>C(O)=O>[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH:5]=[O:7])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 157291712-Formylamino-4-(4-aminophenylthiomethyl)thiazole

생성물 1

HCID 157291722-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole수율 96.7%

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
50 °C

실험 절차

A mixture of acetic anhydride (1.84 g) and formic acid (0.9 g) was heated at 50° C. for 0.5 hours with stirring. The solution was cooled at room temperature and to the solution was added the 2-formylamino-4-(4-aminophenylthiomethyl)thiazole (1.6 g). The mixture was stirred at room temperature for 6.5 hours and then the mixture was poured into ice-water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-formylaminophenylthiomethyl)thiazole (1.7 g, yield: 96.7%). mp: 195°-197° C. (dec.)

후처리

  1. temperatureThe solution was cooled at room temperature and to the solution
  2. stirringThe mixture was stirred at room temperature for 6.5 hours
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-e8bdc1367c2840b8a9a43c3d10efaff9
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256675

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