Hydrochloric Acid → 2-Amino-5-(4-hydroxyphenylthio)thiazole
반응식
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1참가 물질
4
실험 절차
A mixture of 2-acetylamino-5-(4-hydroxyphenylthio)thiazole (1.5 g) in a mixture of ethanol (40 ml) and aqueous 6N hydrochloric acid (6 ml) was refluxed for 4.5 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in water. The solution was adjusted to pH 10 using aqueous sodium hydroxide under ice cooling. The precipitates were collected by filtration and recrystallized from a mixture of ethanol and water (3:1) to give 2-amino-5-(4-hydroxyphenylthio)thiazole (1.05 g, yield: 84.0%). mp: 187°-188° C.
후처리
- temperaturewas refluxed for 4.5 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutionthe residue was dissolved in water
- filtrationThe precipitates were collected by filtration
- customrecrystallized from a mixture of ethanol and water (3:1)
출처 및 근거
- ORD 기록
- ord-42f8b7f420e045bf8712053badbcde08
- 출처 데이터셋
- uspto-grants-1993_10
- 특허 번호
- US05256675
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