Dimethylformamide dimethyl acetal → 3-Ethyl-5-(N-dimethylaminomethylenaminomethyl)-isoxazole

반응식

[NH2:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH3:9])[CH:4]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH2:8]([C:5]1[CH:4]=[C:3]([CH2:2][N:1]=[CH:12][N:13]([CH3:15])[CH3:14])[O:7][N:6]=1)[CH3:9]

참가 물질

반응물 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 6483891(3-Ethyl-1,2-oxazol-5-yl)methanamine

생성물 1

HCID 197869483-Ethyl-5-(N-dimethylaminomethylenaminomethyl)-isoxazole

실험 절차

9 g of 5-aminomethyl-3-ethyl-isoxazole is stirred in 12 ml of dimethylformamide-dimethylacetal with exclusion of moisture for 8 hours at 80° C. (bath temperature). After distillation on a bulb tube at 145° C. and 0.03 torr, 12.8 g (98% of theory) of the desired product is obtained.

후처리

distillationAfter distillation on a bulb tube at 145° C.

출처 및 근거

ORD 기록: ord-8819492e29704cdfa2819f613366d16d
출처 데이터셋: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05256682

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