Hydrochloric Acid → HCID 19787467, 화합물

HRID 1657281노트

반응식

HRID 1657281 반응식
[CH:1]1([C:4]2([CH:10]3[CH2:12][CH2:11]3)[CH2:8][C:7](=[O:9])[CH:6]=[CH:5]2)[CH2:3][CH2:2]1.[H-].C([Al+]CC(C)C)C(C)C.C(OCC)(=O)C.Cl>C(OCC)C>[CH:10]1([C:4]2([CH:1]3[CH2:3][CH2:2]3)[CH2:8][CH:7]([OH:9])[CH:6]=[CH:5]2)[CH2:12][CH2:11]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 19787485HCID 19787485, 화합물HCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 19787467HCID 19787467, 화합물수율 27.8%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 4,4-dicyclopropyl-2-cyclopenten-1-one (1.88 g) in diethyl ether (20 ml) was added diisobutylaluminum hydride (0.94N in n-hexane, 14 ml) at -70° C. to -64° C. under nitrogen atmosphere. After being stirred for 20 minutes, ethyl acetate (6 ml) was added thereto and the solution was acidified with dil. hydrochloric acid and extracted with diethyl ether. The extract was washed with brine, dried over sodium sulfate and evaporated in vacuo to give 4,4-dicyclopropyl-2-cyclopenten-1-ol (0.53 g). Since this compound was not so stable, it was used in the next reaction without purification.

후처리

  1. extractionextracted with diethyl ether
  2. washThe extract was washed with brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e1ae218244c045ee82e99ad4c8f992d5
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256824

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