1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1657404

반응식

HRID 1657404 반응식
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 46254083-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 124148083-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one수율 34.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.

후처리

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. additionThe reaction mixture was then treated in the same manner as in Example 1
  4. customthe obtained crude crystals
  5. customwere recrystallized from isopropyl alcohol

출처 및 근거

ORD 기록
ord-cacede88fdc148cc8f70e8a89c0ca45c
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960863

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