Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| 반응물 | 3-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 4625408 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 12414808 | 34.8% |
반응 단계
A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03960863 |
| 출처 데이터셋 | uspto-grants-1976_06 |
| ORD ID | ord-cacede88fdc148cc8f70e8a89c0ca45c |
| 출처 메모 | uspto-grants-1976_06 |