Phosphonic acid → N-methylpyrrolidone-5,5-diphosphonic acid

HRID 1657460

반응식

HRID 1657460 반응식
[CH3:1][NH:2][C:3](=O)[CH2:4][CH2:5][C:6]([OH:8])=O.[OH:10][PH:11]([OH:13])=[O:12].P(Cl)(Cl)Cl>O>[CH3:1][N:2]1[C:3]([P:11]([OH:13])(=[O:10])[OH:12])([P:11]([OH:13])(=[O:10])[OH:12])[CH2:4][CH2:5][C:6]1=[O:8]

참가 물질

5

반응물 3

HCID 407Phosphonic acidHCID 24387Phosphorus trichlorideHCID 2920503-(Methylcarbamoyl)propanoic acid

생성물 1

HCID 12886162N-methylpyrrolidone-5,5-diphosphonic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

28.5 gm of succinic acid monomethylamide (0.216 mol) were melted with 35.4 gm of H3PO3 (0.432 mol) at 70°C and then slowly mixed with 37.8 ml of PCl3 (0.432 mol). After an additional 5 hours at 70°C, the product was hydrolyzed with 300 ml of H2O. Filtration with activated carbon at the boiling point yielded a clear solution from which the N-methylpyrrolidone-5,5-diphosphonic acid was precipitated with ethanol and acetone. Crude yield 4.2 gm (7% of the theory).

후처리

  1. filtrationFiltration with activated carbon at the boiling point

출처 및 근거

ORD 기록
ord-03c27f84e5744cf1996243df3e845b70
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960888

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