Pyridine → HCID 68142511, 화합물

HRID 1657497노트

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HRID 1657497 반응식
[CH2:1]([N:3]([CH2:6][C:7]1[CH2:8][C@@H:9]2[C@@H:25]([C@:26]3([CH3:33])[C:31]=1[CH2:30][C@@H:29]([OH:32])[CH2:28][CH2:27]3)[CH2:24][CH2:23][C@@:22]1([CH3:34])[C@H:10]2[CH2:11][CH2:12][C@@H:13]1[C@H:14]([CH3:21])[CH2:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:4][CH3:5])[CH3:2].N1C=CC=CC=1.[C:41](Cl)(=[O:44])[CH2:42][CH3:43].C(=O)(O)[O-].[K+]>O>[CH2:4]([N:3]([CH2:6][C:7]1[CH2:8][C@@H:9]2[C@@H:25]([C@:26]3([CH3:33])[C:31]=1[CH2:30][C@@H:29]([O:32][C:41](=[O:44])[CH2:42][CH3:43])[CH2:28][CH2:27]3)[CH2:24][CH2:23][C@@:22]1([CH3:34])[C@H:10]2[CH2:11][CH2:12][C@@H:13]1[C@H:14]([CH3:21])[CH2:15][CH2:16][CH2:17][CH:18]([CH3:19])[CH3:20])[CH2:1][CH3:2])[CH3:5]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 62324Propionyl chlorideHCID 191548(1R,3aS,3bS,7S,9aR,9bS,11aR)‐5‐[(Diethylamino)methyl]‐9a,11a‐dimethyl‐1‐[(2R)‐6‐ methylheptan‐2‐yl]‐ 1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH‐cyclopenta[a]phenanthren‐7‐olHCID 516893Potassium Bicarbonate

생성물 1

HCID 68142511HCID 68142511, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 10 parts of 6-(diethylaminomethyl)cholest-5-en-3β-ol in 40 parts of pyridine at 0° is added, slowly and with stirring, 5 parts of propionyl chloride. When the addition is complete, stirring is continued for 2 hours while the reaction mixture warms to room temperature, whereupon 100 parts of water and 100 parts of aqueous 5% potassium bicarbonate are consecutively mixed in. The oil which separates is extracted with hexane. The extract is washed with water, dried over anhydrous sodium sulfate, and stripped of solvent by vacuum distillation, affording 6-(diethylaminomethyl)-3β-(propionyloxy)cholest-5-ene as the residue.

후처리

  1. additionWhen the addition
  2. stirringstirring
  3. additionare consecutively mixed in
  4. extractionThe oil which separates is extracted with hexane
  5. washThe extract is washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationstripped of solvent by vacuum distillation

출처 및 근거

ORD 기록
ord-400ce63836d14681b6213510c204913a
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960904

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