Sodium Hydroxide → 2-Azido-2-methoxyacetic acid

HRID 1658004노트

반응식

HRID 1658004 반응식
[OH-].[Na+].[N:3]([CH:6]([O:11][CH3:12])[C:7]([O:9]C)=[O:8])=[N+:4]=[N-:5]>CO>[N:3]([CH:6]([O:11][CH3:12])[C:7]([OH:9])=[O:8])=[N+:4]=[N-:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20357785Methyl 2-azido-2-methoxyacetate

생성물 1

HCID 215299592-Azido-2-methoxyacetic acid수율 93.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Aqueous sodium hydroxide (30 ml. of a 2.5 N solution) is added dropwise over 15 minutes to a stirring solution of methyl 2-azido-2-methoxyacetate (10.40 g., 72 mmole) in methanol (8.5 ml.). The mixture becomes warm and cloudy during the addition. The methanol is removed under reduced pressure and the aqueous residue is acidified to pH 1 with concentrated sulfuric acid and extracted with ether. The combined ethereal extracts are dried over sodium sulfate and evaporated in vacuo to leave 2-azido-2-methoxyacetic acid (8.82 g.) as a clear liquid.

후처리

  1. temperatureThe mixture becomes warm and cloudy during the addition
  2. customThe methanol is removed under reduced pressure
  3. extractionextracted with ether
  4. dry with materialThe combined ethereal extracts are dried over sodium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-44b71b0eef774d209f3f4bd62c86c095
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962224

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