Methanol → HCID 53872663, 화합물

반응식

[Na].CO[CH:4]([CH3:7])[C:5]#[N:6].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:15]=[C:16]2[O:20][CH2:19][O:18][C:17]=12)[CH:13]=O.[CH3:21][OH:22]>>[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:15]=[C:16]2[O:20][CH2:19][O:18][C:17]=12)[CH:13]=[C:4]([CH2:7][O:22][CH3:21])[C:5]#[N:6]

참가 물질

반응물 4

HCID 887Methanol2회

HCID 220161,3-Benzodioxole-5-carboxaldehyde, 7-methoxy-

HCID 1418292-Methoxypropanenitrile

HCID 5360545Sodium

생성물 1

HCID 53872663HCID 53872663, 화합물

실험 절차

3.8 g. of sodium were dissolved in 120 ml. of methanol under reflux. 56 g. of methoxypropionitrile and 60 g. of 3-methoxy-4,5-methylenedioxybenzaldehyde were then added and refluxed in the methanol mixture for 5 hours. Upon chilling, 3-methoxy-4,5-methylenedioxy-α-methoxymethyl-cinnamonitrile crystallized in needles of m.p. = 115°, in a yield of 68 g. = 83 percent. A sample of analysis was recrystallized from methanol, m.p. 115.5°-116.5°.

후처리

temperatureUpon chilling
custom3-methoxy-4,5-methylenedioxy-α-methoxymethyl-cinnamonitrile crystallized in needles of m.p. = 115°, in a yield of 68 g
customA sample of analysis was recrystallized from methanol, m.p. 115.5°-116.5°

출처 및 근거

ORD 기록: ord-7d46f5eb344942c394e504ee91dd2aa3
출처 데이터셋: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03962435

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