Sodium Hydroxide → HCID 21529154, 화합물

HRID 1658318노트

반응식

HRID 1658318 반응식
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([O:17]C)=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][C:9]2[C:10]([C:15]([OH:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=2)=[CH:19][CH:20]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14277622Methyl 3-[[(4-methoxyphenyl)methyl]thio]-2-pyridinecarboxylate

생성물 1

HCID 21529154HCID 21529154, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 3 g. of methyl 3-(p-methoxybenzylthio)picolinate in 50 ml. of ethanol is added 10 ml. of 20% aqueous sodium hydroxide solution and the mixture is warmed on a steam bath for two hours. The alcohol is evaporated off and the residue is cooled and acidified with dilute hydrochloric acid. The precipitate is filtered off, washed with water, dried and recrystallized from methanol to give 3-(p-methoxybenzylthio)picolinic acid, m.p. 170°-172°C.

후처리

  1. customThe alcohol is evaporated off
  2. temperaturethe residue is cooled
  3. filtrationThe precipitate is filtered off
  4. washwashed with water
  5. customdried
  6. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-f3ca85deaeb0490bbe97aa24c2ed272e
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03963733

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