3-Trifluoromethylisobutyranilide → Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

HRID 1658671

반응식

HRID 1658671 반응식
[B-](F)(F)(F)F.[CH3:6][CH2:7][O+](CC)CC.[F:13][C:14]([F:28])([F:27])[C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][CH:26]=1)[NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21]>ClCCl>[CH2:6]([O:23][C:19](=[N:18][C:17]1[CH:24]=[CH:25][CH:26]=[C:15]([C:14]([F:27])([F:28])[F:13])[CH:16]=1)[CH:20]([CH3:22])[CH3:21])[CH3:7]

참가 물질

4

반응물 2

HCID 1372643-TrifluoromethylisobutyranilideHCID 2723982Triethyloxonium tetrafluoroborate

생성물 1

HCID 21528116Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Add a solution of 5.0 g. (0.03 moles) of triethyloxonium fluoborate in 13 ml. of dichloromethane to a solution of 7.3 g. (0.03 moles) of 3'-trifluoromethylisobutyranilide in 60 ml. of dichloromethane and reflux for 20 hours. Remove 50 ml. of dichloromethane and add 150 ml. of dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

후처리

  1. additionAdd a solution of 5.0 g
  2. customRemove 50 ml
  3. additionof dichloromethane and add 150 ml
  4. customof dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.

출처 및 근거

ORD 기록
ord-9ca430cf61254486bff17b0e0f712086
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03965176

연결된 노트

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