Sodium borohydride → HCID 21505599, 화합물

HRID 1658805노트

반응식

HRID 1658805 반응식
Cl([O-])(=O)(=O)=O.[F:6][C:7]1[CH:28]=[CH:27][C:10]([C:11]([CH2:13][CH2:14][CH2:15][N+:16]2[CH:21]=[CH:20][C:19]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)=[CH:18][CH:17]=2)=[O:12])=[CH:9][CH:8]=1.[BH4-].[Na+]>CO>[F:6][C:7]1[CH:28]=[CH:27][C:10]([CH:11]([OH:12])[CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)[CH2:20][CH2:21]2)=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 713968301-[4-(4-Fluorophenyl)-4-oxobutyl]-4-(1,3-oxazol-2-YL)pyridin-1-ium perchlorate

생성물 1

HCID 21505599HCID 21505599, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 1.75 g. portion of 1-(3-p-fluorobenzoylpropyl)-4-(2-oxazolyl)pyridinium perchlorate, prepared as described in Example 9, in 75 ml. of methanol, is added portionwise with stirring 1.75 g. of sodium borohydride. The mixture is stirred for 11/2 hours, allowed to stand, some of the methanol is evaporated and the mixture is poured into ice water causing the formation of a tan solid which is recovered by filtration, m.p. 100°-103°C.

후처리

  1. stirringThe mixture is stirred for 11/2 hours
  2. customsome of the methanol is evaporated
  3. additionthe mixture is poured into ice water causing the formation of a tan solid which
  4. filtrationis recovered by filtration, m.p. 100°-103°C.

출처 및 근거

ORD 기록
ord-6855b6ae384f44e5835ca27f3597d9fa
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966748

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