Carbon Dioxide → 3-(2′-Chloro[1,1′-biphenyl]-4-yl)-2-propenoic acid

HRID 1659064

반응식

HRID 1659064 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.C(O)(=O)[CH2:17][C:18]([OH:20])=[O:19].N1CCCCC1.C(=O)=O.Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:15]=[CH:14][C:11]([CH:12]=[CH:17][C:18]([OH:20])=[O:19])=[CH:10][CH:9]=1

참가 물질

7

반응물 5

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 13944002'-Chloro[1,1'-biphenyl]-4-carbaldehyde

생성물 1

HCID 545348143-(2′-Chloro[1,1′-biphenyl]-4-yl)-2-propenoic acid

시약·촉매·용매 1

HCID 1049Pyridine촉매

실험 절차

A mixture of 21.6 g. (0.1 mole) of 4-(2'-chlorophenyl)benzaldehyde is heated on a steam bath with 13.2 g. of malonic acid and 95 ml. of pyridine containing 5 drops of piperidine. The mixture is heated for four hours until the liberation of carbon dioxide ceases. The cooled mixture is poured into a mixture of 110 ml. concentrated hydrochloric acid and 500 ml. of ice water. The solid which separates is filtered, washed and 15 ml. portions of cold water and then resuspended in 200 ml. of cold water, filtered, washed with cold water and dried at 40°C. The residue is then recrystallized from ethanol to obtain 4-(2'-chlorophenyl)cinnamic acid.

후처리

  1. additionA mixture of 21.6 g
  2. additionThe cooled mixture is poured into a mixture of 110 ml
  3. filtrationThe solid which separates is filtered
  4. washwashed
  5. filtrationof cold water, filtered
  6. washwashed with cold water
  7. customdried at 40°C
  8. customThe residue is then recrystallized from ethanol

출처 및 근거

ORD 기록
ord-892152934a76453b9e213d4fb110d525
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966801

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