Thionyl Chloride → beta-(2'-Chloro-4-biphenylyl)propionyl chloride

HRID 1659067

반응식

HRID 1659067 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=1.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([Cl:21])=[O:18])=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 1394276beta-(2'-Chloro-4-biphenylyl)propionic acid

생성물 1

HCID 21526230beta-(2'-Chloro-4-biphenylyl)propionyl chloride

반응 조건

온도
60 °C

실험 절차

β-(2'-chloro-4-biphenylyl)propionic acid (26 g.) is treated with thionyl chloride (18 g.) at 0°-5°C. After 10 mins the temperature is raised to 60°C for 30 mins, then the residue is distilled at 0.05 mm to give β-(2'-chloro-4-biphenylyl)propionyl chloride.

후처리

  1. distillationthe residue is distilled at 0.05 mm

출처 및 근거

ORD 기록
ord-1cf2ddcaced44d57af0b1b597587984a
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966801

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