Methyl Isocyanate → 3-Isopropyl-2-[O-(methylcarbamoyl) oximino]-4-thiazolidinone
반응식
[CH:1]([N:4]1[C:8](=[O:9])[CH2:7][S:6][C:5]1=[N:10][OH:11])([CH3:3])[CH3:2].[CH3:12][N:13]=[C:14]=[O:15]>CC(C)=O.C(#N)C.C(N(CC)CC)C>[CH:1]([N:4]1[C:8](=[O:9])[CH2:7][S:6][C:5]1=[N:10][O:11][C:14](=[O:15])[NH:13][CH3:12])([CH3:3])[CH3:2]참가 물질
5
실험 절차
To a solution of 1.0 g of 3-isopropyl-2-oximino-4-thiazolidinone in 50 ml acetone-acetonitrile solution (1:1) was added 1 ml of methylisocyanate and 5 drops of triethylamine. The reaction mixture was placed in a pressure bottle and left overnight at ambient temperature. After concentrating under vacuo the residual oil was diluted with diethylether. On cooling the product crystallized. Recrystallized from ethyl ether. Weight 1.8 g. m.p. 94°-96°C.
후처리
- concentrationAfter concentrating under vacuo the residual oil
- additionwas diluted with diethylether
- temperatureOn cooling the product
- customcrystallized
- customRecrystallized from ethyl ether
출처 및 근거
- ORD 기록
- ord-a617895ddbfa447f9667cda27f19deeb
- 출처 데이터셋
- uspto-grants-1976_06
- 특허 번호
- US03966953
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