Acetic Anhydride → Quinezamide

반응식

[NH2:1][C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[CH3:15].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[NH:1]([C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[CH3:15])[C:16]([CH3:17])=[O:18]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 20560264HCID 20560264, 화합물

생성물 1

HCID 3052771Quinezamide수율 89%

실험 절차

1-Amino-5-methylpyrazolo[1,5-c]quinazoline is treated with acetic anhydride as described in Example 5 to give 1-acetamino-5-methylpyrazolo[1,5-c]quinazoline. M.p.: 258°-260° C. Yield: 89%.

출처 및 근거

ORD 기록: ord-1b9be80e98ac4a64b1616b866c2c7d9c
출처 데이터셋: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04303660

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