Acetic Anhydride → 2-Acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid

HRID 1659648노트

반응식

HRID 1659648 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:13])([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>O>[C:20]([O:13][C:8]([C:6]1[CH:5]=[CH:4][C:3]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:2]([F:1])[CH:7]=1)([CH3:12])[C:9]([OH:11])=[O:10])(=[O:22])[CH3:21]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 233109062-(2-Fluorobiphenyl-4-yl)-2-hydroxypropanoic acid

생성물 1

HCID 205597762-Acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

(+)-2-(2-Fluoro-4-biphenylyl)-2-hydroxypropionic acid (1 g.) from Example 42 was added to acetic anhydride (10 g.) and the mixture stirred overnight at room temperature. The mixture was added to water (40 ml.) and allowed to stand for two hours. The product was collected and recrystallised from a mixture of ether and light petroleum (b.p. 62°-68° C.) to give (-)-2-acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid, m.p. 125°-127° C. and [α]D20 -33.0°.

후처리

  1. waitto stand for two hours
  2. customThe product was collected
  3. customrecrystallised from a mixture of ether and light petroleum (b.p. 62°-68° C.)

출처 및 근거

ORD 기록
ord-9d56491a46f347d1a57afa58104026dc
출처 데이터셋
uspto-grants-1981_12
특허 번호
US04304931

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