O-Xylene → 2-Stearamidoethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

HRID 1659899

반응식

HRID 1659899 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].O[CH2:22][CH2:23][NH:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].C1(C)C(C)=CC=CC=1>CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].[Ti+4].O>[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][CH2:17][C:18]([O:20][CH2:22][CH2:23][NH:24][C:25](=[O:43])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:19])[CH:8]=[C:9]([C:12]([CH3:13])([CH3:14])[CH3:15])[C:10]=1[OH:11])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 3

HCID 7237O-XyleneHCID 27902N-StearoylethanolamineHCID 883893-(3',5'-Di-tert-butyl-4'-hydroxyphenyl)propionic acid

생성물 1

HCID 205584912-Stearamidoethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

시약·촉매·용매 2

HCID 21801Titanium tetrabutoxide촉매HCID 962Water용매

실험 절차

A mixture of 30.6 g (0.11 mole) 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid, 32.6 g (0.1 mole) N-(2-hydroxyethyl)stearamide, 0.8 g Tyzor TBT, and 100 ml xylene was refluxed for six hours. The water (1.8 ml) was trapped in a Stark & Dean trap. The solution was filtered through Microcel (trademark, synthetic calcium silicate) and the solvent was removed by vacuum stripping. The title compound (51 g) was recrystallized from acrylonitrile. It melted at 52°-55° C.

후처리

  1. temperaturewas refluxed for six hours
  2. filtrationThe solution was filtered through Microcel (trademark, synthetic calcium silicate)
  3. customthe solvent was removed by vacuum stripping
  4. customThe title compound (51 g) was recrystallized from acrylonitrile

출처 및 근거

ORD 기록
ord-17febe92b6be438884d353ab4e1d39ed
출처 데이터셋
uspto-grants-1981_12
특허 번호
US04305868

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