2-Naphthol → 1,8-Bis (2-naphthoxy) octane

HRID 1660109노트

반응식

[Na].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:12].BrCCCCCCCCBr.[CH:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][C:24]=1[O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>>[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][O:33][C:24]1[CH:25]=[CH:26][C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]=1

참가 물질

반응물 4

HCID 86632-Naphthol

HCID 783101,8-Dibromooctane

HCID 5360545Sodium

HCID 14718441HCID 14718441, 화합물

생성물 1

HCID 130554851,8-Bis (2-naphthoxy) octane

실험 절차

Using the method described in Example 1, the crude solids were prepared using 5.5 g (0.24 gram atoms) sodium metal, 34.6 g (0.24 mole) 2-naphthol, and 27.2 g (0.100 mole) 1,8-dibromooctane. Recrystallization from ethyl acetate gave 30.0 g, mp 128° C., and 0.8 g, mp 125°-126° C., of pure 1,8-bix (2-naphthoxy) octane. The NMR spectrum was consistent with the structure and showed the absence of impurities.

후처리

customthe crude solids were prepared
customRecrystallization from ethyl acetate
customgave 30.0 g, mp 128° C., and 0.8 g, mp 125°-126° C.

출처 및 근거

ORD 기록: ord-911d231d6fb646a1a98f5ef0c38c40d4
출처 데이터셋: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04307077

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