Sodium hydride → HCID 24955304, 화합물

HRID 1661466노트

반응식

HRID 1661466 반응식
[CH3:1][C@@H:2]1[C@@H:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:3]1[S:11]([CH3:14])(=[O:13])=[O:12].[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([SH:31])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:18][CH:17]=1.[H-].[Na+]>C1COCC1>[F:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([S:31][C@H:4]([C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=4)[C@@H:2]([NH:3][S:11]([CH3:14])(=[O:13])=[O:12])[CH3:1])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 16112501HCID 16112501, 화합물HCID 593397121-(4-Fluorophenyl)-1H-indazole-5-thiol

생성물 1

HCID 24955304HCID 24955304, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To (2R,3R)-2-methyl-1-(methylsulfonyl)-3-phenylaziridine (38a, 0.03 g, 0.14 mmol) in THF (4 ml) was added 1-(4-Fluorophenyl)-1H-indazole-5-thiol (37c, 0.038 g, 0.16 mmol) and sodium hydride (5.11 mg, 0.21 mmol) on an ice bath with stirring. The ice bath was removed and the mixture was stirren at room temperature over night. The solvent was removed and the mixture was purified on HPLC. Yield 0.007 g (11%).

후처리

  1. customThe ice bath was removed
  2. waitthe mixture was stirren at room temperature over night
  3. customThe solvent was removed
  4. customthe mixture was purified on HPLC

출처 및 근거

ORD 기록
ord-e8f7abd7afdf4d90b628df57a5e0b1e0
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030340B2

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