Diethyl Ether → 1-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole

HRID 1661988노트

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HRID 1661988 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][C:3]=1[OH:11].C([O:14][CH2:15][CH3:16])C.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:11][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:2]=1[Br:1])[N:8]([C:15](=[O:14])[CH3:16])[N:7]=[CH:6]2)(=[O:19])[CH3:18]

참가 물질

4

반응물 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 591599466-Bromo-1H-indazol-5-ol

생성물 1

HCID 667671231-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole수율 98%

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온도
110 °C

실험 절차

A mixture of 6-bromo-5-hydroxy-1H-indazole (25 g, 117 mmol) in acetic acid anhydride (75 mL) is heated at 110° C. with stirring for 2 hours. After it is cooled, diethyl ether (100 mL) is added. The precipitate is collected by filtration, washed with diethyl ether (30 mL), and dried under vacuum to afford the product (34 g, 98% yield). MS (m/z): 297.0 (M+H).

후처리

  1. temperatureAfter it is cooled
  2. filtrationThe precipitate is collected by filtration
  3. washwashed with diethyl ether (30 mL)
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-10c222a328d84374bbe9263e5fb2ace3
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030302B2

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