(4-Bromopyridin-2-yl)methanol → 4-Bromopyridine-2-carbaldehyde

HRID 1662192노트

반응식

HRID 1662192 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[CH:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[O:9])[CH:3]=1

참가 물질

4

반응물 1

HCID 14761462(4-Bromopyridin-2-yl)methanol

생성물 1

HCID 147614724-Bromopyridine-2-carbaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

Manganese(IV) oxide (22.19 g, 255.29 mmol) was added to a solution of (4-bromopyridin-2-yl)methanol (4.00 g, 21.27 mmol) in chloroform (80 mL) and the reaction mixture was stirred under reflux for 45 min. After the mixture had cooled to room temperature the solids were removed by filtration through a pad of Celite®. The solvent was removed in vacuo and the residue (3.96 g, quant.) was used without further purification in the next step.

후처리

  1. temperatureunder reflux for 45 min
  2. customwere removed by filtration through a pad of Celite®
  3. customThe solvent was removed in vacuo
  4. customthe residue (3.96 g, quant.) was used without further purification in the next step

출처 및 근거

ORD 기록
ord-960d209e97eb4111b6bd7889b0d46f0a
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030500B2

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