Hydrochloric Acid → (2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

HRID 1662684노트

반응식

HRID 1662684 반응식
[CH3:1][N:2]([CH3:18])[C:3]([C@@H:5]1[CH2:9][C@@H:8]([OH:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)=[O:4].[ClH:19]>CCOC(C)=O>[ClH:19].[OH:10][C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([N:2]([CH3:18])[CH3:1])=[O:4])[CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 25180889(2S,4R)-tert-butyl 2-(dimethylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

생성물 1

HCID 23535508(2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of 11.0 g of the compound obtained in Step 88-1 in EtOAc (100 ml) was added dropwise a solution of 4 mol/l hydrochloric acid in EtOAc (100 ml) over 20 minutes. The solution was stirred at room temperature for two hours and then the solvent was evaporated under reduced pressure. EtOAc was added, and the solution was stirred for 30 minutes. Thereafter, the precipitated solid was filtered and then dried to obtain 8.21 g of the title compound (colorless solid).

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionEtOAc was added
  3. stirringthe solution was stirred for 30 minutes
  4. filtrationThereafter, the precipitated solid was filtered
  5. customdried

출처 및 근거

ORD 기록
ord-2acaf965bcff49daa4c1497e3f458349
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030499B2

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