Water → HCID 18736636, 화합물
반응식
CI.[F:3][CH:4]([F:13])[O:5][C:6]1[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=1.[C:14]([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[F:3][CH:4]([F:13])[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:14])[CH:7]=1참가 물질
6
실험 절차
2.67 g of methyl iodide was stirred on ice in a suspension of 2.00 g of 3-difluoromethoxy phenol and 2.60 g of K2CO3 in DMF (10 ml) at room temperature for two hours. Water was added to the solution and the resulting mixture was extracted with Et2O; the organic layer was washed with saturated brine and then dried over MgSO4; the drying agent was separated by filtration, and the solvent was evaporated under reduced pressure obtained 46.0 g of the title compound (crude form).
후처리
- extractionthe resulting mixture was extracted with Et2O
- washthe organic layer was washed with saturated brine
- dry with materialdried over MgSO4
- customthe drying agent was separated by filtration
- customthe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-899b08c2cdff46f19bf6c95af998010d
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08030499B2
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