5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH:12]1([C:18](Cl)=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C1COCC1>[Cl:11][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:18]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:19])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]참가 물질
4
실험 절차
A solution of 5-amino-2-chlorobenzoic acid (0.34 g, 2.0 mmol) in THF (10 mL) was charged with cyclohexanecarbonyl chloride (0.27 mL, 1.7 mmol). The reaction was stirred for 16 h and then concentrated in vacuo. The residue was suspended in DCM and filtered to afford the title compounds as a white solid (0.47 g, 97%).
후처리
- concentrationconcentrated in vacuo
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-c95b7900514f4738a107f2e40adbe181
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08030487B2
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