Diisopropylethylamine → HCID 67435948, 화합물

HRID 1663368노트

반응식

HRID 1663368 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:12]2[C:21]3[C:20](=[O:22])[CH2:19][CH:18]([CH2:23][CH2:24][CH3:25])[CH2:17][C:16]=3[NH:15][C:14]([CH3:26])=[C:13]2[C:27]#[N:28])[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[OH:8].C(N(CC)C(C)C)(C)C.[CH3:38][O:39][C:40]1[CH:48]=[CH:47][CH:46]=[CH:45][C:41]=1[C:42](Cl)=[O:43]>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH:12]2[C:21]3[C:20](=[O:22])[CH2:19][CH:18]([CH2:23][CH2:24][CH3:25])[CH2:17][C:16]=3[NH:15][C:14]([CH3:26])=[C:13]2[C:27]#[N:28])[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[O:8][C:42](=[O:43])[C:41]1[CH:45]=[CH:46][CH:47]=[CH:48][C:40]=1[O:39][CH3:38]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 889692-Methoxybenzoyl chlorideHCID 67435380HCID 67435380, 화합물

생성물 1

HCID 67435948HCID 67435948, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 4-(3-bromo-4-hydroxy-5-nitro-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile (200 mg), N,N-diisopropylethylamine (390 μl) and 2-methoxy-benzoyl chloride (53 μl) in dichloromethane (4 ml) was stirred for 4 h. The mixture was diluted with dichloromethane and washed with water. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

후처리

  1. washwashed with water
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4e27315b291f461cbc7fb0274622bc83
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08034945B2

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