Sodium Hydroxide → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

HRID 1663637노트

반응식

HRID 1663637 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([O:10]CC)=[O:9])=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([OH:10])=[O:9])=[N:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10749618ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid수율 41.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Using ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (440 mg, 2.62 mmol), 1N aqueous sodium hydroxide solution (3 mL, 3 mmol) and ethanol (3 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (152 mg, 41%) was obtained as pale-yellow crystals.

후처리

  1. customby a reaction in the same manner as in Reference Example 20

출처 및 근거

ORD 기록
ord-664c37f6d3494bb4a3ba7dd38434d8f8
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08034812B2

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