Adipic Dihydrazide → Ceftiofur

HRID 1664085

반응식

HRID 1664085 반응식
[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([OH:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1.Cl.C(NN)(=O)CCCCC(NN)=O>>[CH3:1][O:2]/[N:3]=[C:4](\[C:11]([NH:13][C@@H:14]1[C:17](=[O:18])[N:16]2[C:19]([C:32]([OH:34])=[O:33])=[C:20]([CH2:23][S:24][C:25]([C:27]3[O:31][CH:30]=[CH:29][CH:28]=3)=[O:26])[CH2:21][S:22][C@H:15]12)=[O:12])/[C:5]1[N:9]=[C:8]([NH2:10])[S:7][CH:6]=1

참가 물질

3

반응물 2

HCID 66117Adipic DihydrazideHCID 9937686Ceftiofur Hydrochloride

생성물 1

HCID 6328657Ceftiofur

실험 절차

Ceftiofur-HCl (50 mg) and adipic acid dihydrazide (10 mg) were placed in a 1-ml syringe. This syringe was connected to a second syringe containing 1 ml of oxidized dextran (Mw, 500,000; 85 mg/ml; 1 ml). The contents of the two syringes were mixed by making 20 reciprocations. A sample (200 μl) of the reaction mixture was transferred to a 2 ml centrifuge tube for the release experiment in PBS buffer. The release profile matrix appears in Table 4 below:

후처리

  1. customThis syringe was connected to a second syringe
  2. additionThe contents of the two syringes were mixed

출처 및 근거

ORD 기록
ord-05e54cf90ea34273886245aa501c9011
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039021B2

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