Hydrochloric Acid → 870562-26-8
반응식
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([F:13])=[CH:5][CH:4]=1)#[N:2].[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1참가 물질
5
실험 절차
A solution of 1-cyano-4-fluoronapthalene (1.05 g, 6.12 mmol) and 1.5 mL of HCl (aq.) in absolute ethanol (50 mL) was stirred under a hydrogen atmosphere (balloon) with 10% palladium on carbon (0.20 g) for 16 hours. The catalyst was removed by filtration through Celite®, and the filtrate concentrated under vacuum. The resulting solid was triturated with ether and collected by filtration to give the title compound (0.575 g, 44% yield) as an off white solid.
후처리
- customThe catalyst was removed by filtration through Celite®
- concentrationthe filtrate concentrated under vacuum
- customThe resulting solid was triturated with ether
- filtrationcollected by filtration
출처 및 근거
- ORD 기록
- ord-58a07d8afd314eb8ad52cd16eec93d0c
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08039458B2
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