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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → Hydrochloric Acid

HRID 1664612
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인쇄 미리보기

반응식

HRID 1664612 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[C:18]([CH3:26])[CH:17]=2)=[CH:10][CH:9]=1)(C)(C)C.[ClH:28].C(OCC)C>C(OCC)(=O)C.O1CCOCC1>[CH3:26][C:18]1[CH:17]=[C:16]([CH2:15][O:14][C:11]2[CH:10]=[CH:9][C:8]([NH2:7])=[CH:13][CH:12]=2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=1.[ClH:28]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57562794[4-(2-Methylquinolin-4-ylmethoxy)phenyl]carbamic acid tert-butyl ester

생성물 2

HCID 313Hydrochloric AcidHCID 223927834-((2-Methylquinolin-4-yl)methoxy)aniline

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매
HCID 312751,4-Dioxane용매

실험 절차

To a solution of compound [4-(2-methylquinolin-4-ylmethoxy)phenyl]carbamic acid tert-butyl ester (1.5 g) in ethyl acetate (5 mL) was added 4 N HCl in dioxane (20 mL) and the mixture was stirred at room temperature for 3 h. Ethyl ether was added and the precipitate was filtered and washed with ethyl ether to provide 4-(2-methylquinolin-4-ylmethoxy)phenylamine as an HCl salt (1.3 g). ESI (M+H)+ 265.0.

후처리

  1. filtrationthe precipitate was filtered
  2. washwashed with ethyl ether

출처 및 근거

ORD 기록
ord-5fb41566ad994bff92289b73b563e400
출처 데이터셋
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08039471B2

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