Tetrafluoroboric acid → 5-Bromo-2-methylbenzenediazonium tetrafluoroborate
반응식
[N:1]([O-])=O.[Na+].[CH3:5][C:6]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][C:7]=1[NH2:8].[F:14][B-:15]([F:18])([F:17])[F:16].[H+]>O>[F:14][B-:15]([F:18])([F:17])[F:16].[Br:13][C:10]1[CH:11]=[CH:12][C:6]([CH3:5])=[C:7]([N+:8]#[N:1])[CH:9]=1참가 물질
5
실험 절차
Sodium nitrite (0.56 g) in water (2.0 mL) was slowly added to a mixture of 2-methyl-5-bromoaniline (1.50 g) in tetrafluoroboric acid (6.0 mL) and water (4.0 mL) at 0-5° C. After addition, the reaction was stirred at room temperature for 30 min. The mixture was cooled to 0° C., filtered, washed with cold water, cold methanol and ether. The mixture was then dried to provide the product 5-bromo-2-methylphenyldiazonium tetrafluoroborate (1.90 g).
후처리
- additionAfter addition
- temperatureThe mixture was cooled to 0° C.
- filtrationfiltered
- washwashed with cold water, cold methanol and ether
- customThe mixture was then dried
출처 및 근거
- ORD 기록
- ord-4f622eabefaf4e3ba627cef4b3869ab0
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08039471B2
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