Methyl iodide → 6-Bromo-1-methyl-1H-indazole
반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.[OH-].[K+].[CH3:13]I>CO.C(OCC)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:13])=[CH:4][CH:3]=1참가 물질
6
실험 절차
6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.
후처리
- temperaturethe mixture was refluxed for 2.5 h
- temperatureThe reaction was cooled
- washwashed with water, brine
- customdried
- concentrationconcentrated
- customThe product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash
출처 및 근거
- ORD 기록
- ord-f391e8ec558c4f93a563fe826edb395a
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08039471B2
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